It is sometime in the second Millennium. Garrett Oswald, a brilliant scientist, manages to find a means to combine organic and inorganic tissue. This is accomplished through the injection of a special compound that he calls “U”. With the assistance of a highly sophisticated computer running specialized software implanted in the back of the human brain, a subject can learn to completely control their own cells at will. This allows them to remove usual human limitations such as a finite lifespan, irreparable neural injuries, and susceptibility to disease. The end goal was to send these cyborgs, or cygens as they are called, to colonize new worlds in the name of expansion and exploration. Shiki, a near perfect specimen of humanity, becomes the first successful cygen.

However, when the same process is attempted on a male, unexpected results occur. The man is transformed; his mind subsumed into the program and his body merging with and encasing itself in metal, becoming incapable of reproduction and turning him into a emotionless machine. As a result, the cygen project is reclassified as a military application to produce tools for the United States government. Instead of giving these subjects names, they are given armor classes and IDs. Shiki is given the classification: “Omega”. To society at large they do not exist, but are merely secret tools of the government, not even considered truly human.

Following a string of successes and shortcomings, several new cygens emerge, and mankind is on its way to a new golden age…